Key result
Prazosin HCl did not alter forearm vascular conductance during exercise compared to placebo, despite significantly lowering mean arterial pressure (P<0.03) and increasing heart rate (P<0.02).
RCT (n=9)
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Does not warrant changes to prazosin use during exercise; hypothesis-generating for alpha-1 receptor contributions to muscle blood flow.
Kenney et al. (1991) reported an RCT. Prazosin HCl vs. Placebo was evaluated on Forearm vascular conductance (FVC). Prazosin HCl did not alter forearm vascular conductance during exercise compared to placebo, despite significantly lowering mean arterial pressure (P<0.03) and increasing heart rate (P<0.02).
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