Key result
Reduced ACTC1 expression in cardiac tissues of patients with sporadic congenital heart disease was associated with a significantly higher proportion of apoptotic cardiomyocytes compared to controls (5.77% vs 1.25%, P<0.01).
Authors
Loading...
Decreased ACTC1 expression in sporadic CHD should not change practice; leaves open mechanistic role beyond familial defects.
Case-Control (n=45)
No
Absolute Event Rate: 5.77% vs 1.25%
p-value: p=<0.01
Jiang et al. (2010) conducted a case-control in Congenital heart disease (n=45). Reduced ACTC1 expression vs. Normal ACTC1 expression (controls) was evaluated on Proportion of apoptotic cardiomyocytes (TUNEL-positive) (p=<0.01). Reduced ACTC1 expression in cardiac tissues of patients with sporadic congenital heart disease was associated with a significantly higher proportion of apoptotic cardiomyocytes compared to controls (5.77% vs 1.25%, P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: