Key result
Aldosterone measurement by LC-MS/MS yielded values 27.8% lower than RIA, but proposed LC-MS/MS cutoffs showed good diagnostic agreement with current RIA cutoffs (κ=0.736; P<0.01).
Why the study?
Does aldosterone measurement by LC-MS/MS with adjusted cutoffs perform as well as RIA with current cutoffs for primary aldosteronism diagnostic testing?
Population
41 patients undergoing aldosterone/renin ratio testing to screen for, and fludrocortisone suppression…
Comparison
Aldosterone measurement by liquid… vs Aldosterone measurement by radioimmunoassay…
Design
Cohort
Authors
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May support LC-MS/MS with adjusted cutoffs for aldosteronism screening; leaves open prospective validation before practice change.
Observational (n=41)
Does aldosterone measurement by LC-MS/MS with adjusted cutoffs perform as well as RIA with current cutoffs for primary aldosteronism diagnostic testing?
Effect estimate: κ 0.736
p-value: p=<0.01
Aldosterone levels measured by LC-MS/MS are significantly lower than those measured by RIA, necessitating the use of adjusted, lower diagnostic cutoffs which perform comparably to traditional RIA cutoffs for primary aldosteronism testing.
Guo et al. (2018) conducted an observational in Primary aldosteronism (n=41). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) vs. Radioimmunoassay (RIA) was evaluated on Diagnostic agreement between FST diagnostic PACRIA cutoff (165 pmol/L) and proposed PACLC-MS/MS cutoff (133 pmol/L) (κ 0.736, p=<0.01). Aldosterone measurement by LC-MS/MS yielded values 27.8% lower than RIA, but proposed LC-MS/MS cutoffs showed good diagnostic agreement with current RIA cutoffs (κ=0.736; P<0.01).
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