Key result
Selective stimulation of intrarenal production of ANG II in double-transgenic mice significantly augmented endogenous intrarenal mAGT mRNA (ratio 1.46 vs 1.00 in wild-type) and protein expression.
Why the study?
Does selective intrarenal overproduction of ANG II increase endogenous intrarenal mouse angiotensinogen expression in transgenic mice?
Population
39 mice: single transgenic mice expressing human AGT only in the kidney, double-transgenic mice expressing…
Comparison
Double-transgenic expression of human renin… vs Single transgenic mice expressing hAGT only in…
Design
Preclinical
Follow-up
Monitored from 12 to 18 weeks of age
Authors
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Intrarenal ANG II increases mAGT in transgenic mice; leaves open relevance to human hypertension or kidney disease.
Does selective intrarenal overproduction of ANG II increase endogenous intrarenal mouse angiotensinogen expression in transgenic mice?
Absolute Event Rate: 1.46% vs 1%
Selective stimulation of intrarenal production of ANG II from human angiotensinogen augments endogenous intrarenal mouse angiotensinogen mRNA and protein expression in a transgenic mouse model.
Kobori et al. (2007) studied Kidney-specific enhancement of ANG II (n=39). Selective intrarenal overproduction of ANG II vs. Single transgenic and wild-type mice was evaluated on Endogenous renal mAGT mRNA ratio. Selective stimulation of intrarenal production of ANG II in double-transgenic mice significantly augmented endogenous intrarenal mAGT mRNA (ratio 1.46 vs 1.00 in wild-type) and protein expression.
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