Key result
Transfection of decoy ODN against AGE 2, but not AGE 3 or mismatched ODN, resulted in a transient decrease in blood pressure and angiotensinogen levels in spontaneously hypertensive rats.
Why the study?
Does transfection of decoy ODN against AGE 2 or AGE 3 reduce blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Transfection of synthetic double-stranded… vs Mismatched decoy ODN
Design
Preclinical
Authors
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AGE 2 decoy reduces BP in SHR models; leaves open whether angiotensinogen cis-element targeting offers viable human therapy.
Does transfection of decoy ODN against AGE 2 or AGE 3 reduce blood pressure in spontaneously hypertensive rats?
Inhibition of the transcriptional cis-element AGE 2 using decoy oligodeoxynucleotides reduces blood pressure and angiotensinogen production in spontaneously hypertensive rats.
Morishita et al. (1996) studied Hypertension. Decoy oligodeoxynucleotides (ODN) against AGE 2 vs. Mismatched decoy ODN and AGE 3 decoy ODN was evaluated on Blood pressure and angiotensinogen production. Transfection of decoy ODN against AGE 2, but not AGE 3 or mismatched ODN, resulted in a transient decrease in blood pressure and angiotensinogen levels in spontaneously hypertensive rats.
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