Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1995Hypertension

Transient Decrease in High Blood Pressure by In Vivo Transfer of Antisense Oligodeoxynucleotides Against Rat Angiotensinogen

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does transfection of antisense oligonucleotides against rat angiotensinogen reduce blood pressure in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats

Comparison

Transfection of antisense oligonucleotides… vs Transfection of sense and scrambled…

Design

Preclinical

Follow-up

7 days

Authors

NTNaruya TomitaKawasaki Medical SchoolRMRyuichi MorishitaVascular / Pulmonary VascularJHJitsuo HigakiGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for angiotensinogen inhibition in hypertension; requires human trials before any clinical consideration.

Structured PICO

Does transfection of antisense oligonucleotides against rat angiotensinogen reduce blood pressure in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats
I
Intervention
Transfection of antisense oligonucleotides against rat angiotensinogen into the rat liver via the portal vein using liposomes containing viral agglutinins
C
Comparator
Transfection of sense and scrambled oligonucleotides
O
Outcome
Blood pressure and plasma angiotensinogen levelssurrogate

In vivo transfer of antisense oligonucleotides against angiotensinogen transiently decreases blood pressure and angiotensinogen levels in spontaneously hypertensive rats, demonstrating the role of circulating angiotensinogen in blood pressure regulation.

Cite This Study

Tomita et al. (1995) studied this question.

synapsesocial.com/papers/6a7d51baf1daba58ecd5b4fahttps://doi.org/10.1161/01.hyp.26.1.131

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.1984 · 191 citations
  2. 2Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.1993 · 458 citations
  3. 3Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose1972 · 6,889 citations
  4. 4Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes1993 · 268 citations
  5. 5Changes in gene expression of the renin???angiotensin system in two-kidney, one clip hypertensive rats1991 · 49 citations