Why the study?
Does brain-specific down-regulation of angiotensinogen reduce blood pressure in transgenic rats?
Population
Transgenic rats [TGR] expressing an antisense RNA against angiotensinogen mRNA specifically in the brain…
Comparison
Brain-specific down-regulation of… vs Control rats
Design
Preclinical
Authors
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Caution against human extrapolation; extends rodent evidence for brain angiotensinogen in BP regulation.
Does brain-specific down-regulation of angiotensinogen reduce blood pressure in transgenic rats?
Brain-specific down-regulation of angiotensinogen in transgenic rats lowers blood pressure and attenuates hypertensive phenotypes, highlighting the role of local brain angiotensin production in blood pressure regulation.
Schinke et al. (1999) studied this question.
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