Why the study?
Does low brain angiotensinogen alter the long-term and short-term control of blood pressure and heart rate variability in rats during basal and angiotensin II-induced hypertensive conditions?
Population
Transgenic rats [TGR(ASrAOGEN)] with low brain angiotensinogen levels and control rats
Comparison
Low-dose subcutaneous infusion of angiotensin II… vs Control rats receiving the same infusion, and…
Design
Preclinical
Follow-up
7 days
Authors
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Brain angiotensinogen deficiency may blunt Ang II-driven BP rhythm inversion in rats; hypothesis-generating for central RAS in circadian control, human relevance unknown.
Does low brain angiotensinogen alter the long-term and short-term control of blood pressure and heart rate variability in rats during basal and angiotensin II-induced hypertensive conditions?
A permanent deficiency in the brain renin-angiotensin system prevents the inversion of circadian blood pressure rhythm induced by angiotensin II and alters reflex control of heart rate in rats.
Baltatu et al. (2001) studied this question.
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