Key result
Children with polyarteritis nodosa had significantly increased brachioradial pulse wave velocity (mean z score +0.99) compared to healthy controls, indicating decreased arterial distensibility.
Why the study?
Does polyarteritis nodosa alter arterial distensibility in children and teenagers compared to healthy controls?
Population
168 children and teenagers, comprising 13 with polyarteritis nodosa and 155 healthy schoolchildren.
Comparison
Polyarteritis nodosa (childhood vasculitis) vs Healthy schoolchildren
Design
Case-control
Authors
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May indicate vascular involvement in pediatric polyarteritis nodosa; hypothesis-generating for cardiovascular risk monitoring.
Cross-Sectional (n=168)
Does polyarteritis nodosa alter arterial distensibility in children and teenagers compared to healthy controls?
Absolute Event Rate: 0.99% vs 0%
Childhood vasculitis (polyarteritis nodosa) is associated with increased pulse wave velocity and decreased arterial distensibility, which is further amplified during acute inflammatory exacerbations.
Yiu‐fai Cheung (2002) conducted a cross-sectional in Polyarteritis nodosa (n=168). Polyarteritis nodosa vs. Healthy schoolchildren was evaluated on Pulse wave velocity (PWV) of the brachioradial arterial segment (z score). Children with polyarteritis nodosa had significantly increased brachioradial pulse wave velocity (mean z score +0.99) compared to healthy controls, indicating decreased arterial distensibility.
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