Key result
The 5-year incidence of very severe hypertriglyceridemia in Canadian adults with at least one measured triglyceride level was 0.041% (1 in 2500), with diabetes, male sex, and alcohol abuse identified as strong predictors.
Why the study?
The incidence of severe and very severe hypertriglyceridemia among Canadians was unknown.
Population
10,766,770 Ontario adults ≥18 years (7,040,865 with at least one measured TG)
Comparison
Individuals with VS-HTG vs those with no measured TG value > 3 mmol/L
Design
Population-based cohort study using linked administrative healthcare databases
Follow-up
2 years
Authors
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May support targeted triglyceride monitoring in diabetic men with alcohol abuse; leaves open whether screening improves outcomes.
Cohort (n=7,040,865)
Very severe hypertriglyceridemia is rare (1 in 2500 adults) but strongly predicted by diabetes, male sex, and alcohol abuse, highlighting populations that may benefit from targeted surveillance.
Berberich et al. (2021) conducted a cohort in Very severe hypertriglyceridemia (n=7,040,865). Risk factors for very severe hypertriglyceridemia vs. No hypertriglyceridemia (TG ≤ 3 mmol/L) was evaluated on Incidence of very severe hypertriglyceridemia (TG > 20 mmol/L) among adults with at least one measured TG. The 5-year incidence of very severe hypertriglyceridemia in Canadian adults with at least one measured triglyceride level was 0.041% (1 in 2500), with diabetes, male sex, and alcohol abuse identified as strong predictors.
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