Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics
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Key result
Severe hypertriglyceridemia is present in 0.13% of the Norwegian population and is associated with considerable co-morbidity and an imbalance of genes involved in lipid metabolism.
Study Design
Type
Cross-Sectional (n=681,990)
Multicenter
Yes
Structured PICO
P
Population
681,990 participants aged 20 to 103 years from three large Norwegian population surveys were evaluated to determine the prevalence and clinical characteristics of severe hypertriglyceridemia.
O
Outcome
Prevalence of severe hypertriglyceridemia (non-fasting serum triglycerides ≥10 mmol/L)
Severe hypertriglyceridemia has a prevalence of 0.13% in Norway and is associated with significant comorbidities including cardiovascular disease and pancreatitis, as well as altered expression of lipid metabolism genes.
Limitations
- Pooled estimate based on several large surveys may not be fully representative of the general Norwegian population
- Sick people usually participate to a lower extent than healthy people in large population surveys
- Possible confounding due to differences in life-styles
- Fasting TG value was not always available
- Lack of a control group and a participation rate of 58% may have led to a selection bias in the 65 patients with persistent sHTG
- Few patients included in the PBMC sub-study and only male subjects were studied
- Small number of patients in the detailed clinical subset compared to the larger surveys
- Lack of a control group for the treatment follow-up of the 65 patients
- Lack of data regarding the prevalence of heterozygous mutations in the 65 patients
Authors
Discussion
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Implication
Highlights the rare but high-risk clinical profile of severe hypertriglyceridemia; leaves.
Cite This Study
Retterstøl et al. (2017) conducted a cross-sectional in Severe hypertriglyceridemia (n=681,990). Severe hypertriglyceridemia (triglycerides ≥10 mmol/L) vs. General population / Triglycerides <10 mmol/L was evaluated on Prevalence of severe hypertriglyceridemia (95% CI 0.12-0.14). Severe hypertriglyceridemia is present in 0.13% of the Norwegian population and is associated with considerable co-morbidity and an imbalance of genes involved in lipid metabolism.
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