June 1, 1990AJP Heart and Circulatory Physiology
Does volume catheter parallel conductance vary during a cardiac cycle?
Key result
A new method for parallel conductance determination demonstrated that parallel conductance volume remains relatively constant throughout normal ejection in isolated and in situ canine left ventricles.
Population
Isolated blood-perfused ejecting canine left ventricles with empty right ventricles, and in situ hearts
Comparison
New method for parallel conductance… vs Previously published technique yielding a single…
Design
Preclinical
Authors
Discussion
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Implication
Reinforces parallel conductance assumptions in canine models; leaves open human validation and clinical translation.
Key Points
- This study aims to reassess the variability of parallel conductance volume during the cardiac cycle.
- Developed a new method for dynamic parallel conductance estimation during systole.
- Conducted experiments on isolated and in situ canine left ventricles to measure Vp variability.
- Performed volume signal simulations to compare sensitivity to signal noise.
- Vp(t) showed virtually no variation during systole for both isolated and in situ hearts.
- Statistical analysis indicated no significant deviation from the mean value of Vp(t) throughout systole.
- The new technique proved to be more robust against signal noise compared to previous methods.
Structured PICO
P
Population
Isolated blood-perfused ejecting canine left ventricles with empty (vented) right ventricles, and in situ hearts
I
Intervention
New method for parallel conductance determination yielding multiple estimates during systole
C
Comparator
Previously published technique yielding a single value
O
Outcome
Variability of parallel conductance volume [Vp(t)] throughout systolesurrogate
A new method for determining parallel conductance volume demonstrates that parallel conductance remains relatively constant throughout normal ejection in the left ventricle, supporting current volume measurement assumptions.
Cite This Study
Lankford et al. (1990) studied this question. New method for parallel conductance determination vs. Previously published technique was evaluated on Parallel conductance volume (Vp) variability throughout systole. A new method for parallel conductance determination demonstrated that parallel conductance volume remains relatively constant throughout normal ejection in isolated and in situ canine left ventricles.