Key result
An infection risk index ≥ 1 was significantly associated with an increased risk of surgical site infection (OR 6.65; 95% CI 1.04-42.59; P=0.045).
Why the study?
What is the incidence of surgical site infection and the rate of compliance with perioperative antibiotic prophylaxis guidelines in surgical patients?
Cohort (n=249)
What is the incidence of surgical site infection and the rate of compliance with perioperative antibiotic prophylaxis guidelines in surgical patients?
Odds Ratio: 6.65 (95% CI 1.04–42.59)
p-value: p=0.045
There is inadequate compliance with perioperative antibiotic prophylaxis guidelines, and an infection risk index ≥ 1 significantly increases the risk of surgical site infections.
Low PAP compliance (12.4%) observed; leaves open whether improved adherence reduces SSI risk in older surgical patients.
The aims of the present study were to: (1) assess surgical site infection (SSI) incidence in a cohort of surgical patients and (2) estimate the compliance with national guidelines for perioperative antibiotic prophylaxis (PAP). SSIs, among the most common health care-associated infections, are an important target for surveillance and an official priority in several European countries. SSI commonly complicates surgical procedures in older people and is associated with substantial attributable mortality and costs. The implementation of PAP guidelines is difficult among surgeons, and failure to comply with the standard of care has been widely reported. A 12-month prospective survey was performed in accordance with the methods, protocols, and definitions of the Hospital in Europe Link for Infection Control through Surveillance (HELICS) protocol. The compliance of the current PAP practices with the published national guidelines was assessed. A total of 249 patients were enrolled. The cumulative SSI incidence was 3.2 per 100 operative procedures. Cumulative compliance for PAP was 12.4%. Overall, only infection risk index ≥ 1 was confirmed as a significant risk factor for SSI (odds ratio, 6.65; 95% confidence interval, 1.04-42.59; P = 0.045). When only older patients (age >65 years) were considered, no significant risk factors for SSI were identified. Our study indicates an overall inadequate compliance with PAP recommendations, thus highlighting the need to develop multimodal and targeted intervention programs to improve compliance with PAP guidelines.
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Agodi et al. (2015) conducted a cohort in Surgical site infection (n=249). Infection risk index ≥ 1 vs. Infection risk index < 1 was evaluated on Surgical site infection (SSI) (OR 6.65, 95% CI 1.04-42.59, p=0.045). An infection risk index ≥ 1 was significantly associated with an increased risk of surgical site infection (OR 6.65; 95% CI 1.04-42.59; P=0.045).
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