Key result
Coronary ligation in mice induced splenic leukocyte depletion and increased macrophage-dependent generation of specialized proresolving mediators in the infarcted left ventricle within 24 hours.
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May promote early resolution post-MI in mice; leaves open translation to human therapy.
Halade et al. (2018) studied Myocardial infarction and heart failure. Coronary ligation vs. Before myocardial infarction was evaluated on Leukocyte trafficking and specialized proresolving mediators (SPMs) in the infarcted left ventricle and spleen. Coronary ligation in mice induced splenic leukocyte depletion and increased macrophage-dependent generation of specialized proresolving mediators in the infarcted left ventricle within 24 hours.
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