Key result
Dahl-Iwai salt-sensitive rats fed a high salt diet consistently develop compensated concentric left ventricular hypertrophy followed by decompensation with a dilated hypokinetic left ventricle.
Population
Inbred Dahl-Iwai salt-sensitive rats and Dahl-Iwai salt-resistant rats fed a 0.3% NaCl diet until 6 weeks of…
Comparison
8% NaCl diet starting at 6 weeks of age. vs Dahl-Iwai salt-resistant rats receiving the same…
Design
Preclinical
Follow-up
Until natural survival time
Authors
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Establishes Dahl-Iwai rats as model of LVH-to-dilated HF transition; leaves open translation to human salt-sensitive hypertension.
The Dahl-Iwai salt-sensitive rat model provides a reproducible system to study the transition from compensated left ventricular hypertrophy to overt dilated heart failure.
Yasuki Kihara (1997) studied Hypertension and heart failure (n=37). High salt (8% NaCl) diet vs. Dahl-Iwai salt-resistant (DR) rats was evaluated on Natural survival time and left ventricular dimensions. Dahl-Iwai salt-sensitive rats fed a high salt diet consistently develop compensated concentric left ventricular hypertrophy followed by decompensation with a dilated hypokinetic left ventricle.
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