Key result
Female obese ZSF1 rats developed diastolic dysfunction, cardiac hypertrophy, and fibrosis comparable in severity to obese males, establishing them as a relevant model for HFpEF.
Why the study?
HFpEF is more prevalent in females, but while male obese ZSF1 rats are a proposed model for diastolic dysfunction and early HFpEF, studies in female animals have not been performed.
Population
Male and female ZSF1 rats, lean and obese (N = 6-9/subgroup)
Comparison
Female obese vs female lean ZSF1 rats and obese male vs female ZSF1 rats
Design
Animal experimental study
Follow-up
From 12 to 26 weeks of age
Authors
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Does not inform clinical HFpEF care; extends ZSF1 modeling to females and leaves translation open.
Female obese ZSF1 rats develop diastolic dysfunction and cardiac remodeling similar to males, establishing them as a suitable preclinical model for HFpEF with multiple comorbidities.
Nguyen et al. (2020) studied Heart failure with preserved ejection fraction (HFpEF) (n=31). Obesity (obese ZSF1 phenotype) vs. Lean ZSF1 rats was evaluated on Diastolic dysfunction and cardiac remodeling. Female obese ZSF1 rats developed diastolic dysfunction, cardiac hypertrophy, and fibrosis comparable in severity to obese males, establishing them as a relevant model for HFpEF.
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