Key result
Hydrogen ions modulate L-type Ca channel current amplitude in isolated ventricular cells through changes in surface potential (pK 5.8) and an additional unidentified mechanism.
Why the study?
Does hydrogen ion modulation affect L-type Ca channel current in isolated ventricular cells?
Population
Isolated ventricular cells
Comparison
Hydrogen ion modulation vs pH 7.4 solution
Design
Preclinical
Authors
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May alter ventricular Ca influx in acid-base disorders; extends surface potential theory but leaves clinical translation open.
Does hydrogen ion modulation affect L-type Ca channel current in isolated ventricular cells?
Hydrogen ions modulate L-type calcium channel currents in ventricular cells through multiple mechanisms, including changes in surface potential.
Krafte et al. (1988) studied Isolated ventricular cells. Hydrogen ion modulation (pH changes) vs. pH 7.4 was evaluated on L-type Ca channel current amplitude and gating shifts. Hydrogen ions modulate L-type Ca channel current amplitude in isolated ventricular cells through changes in surface potential (pK 5.8) and an additional unidentified mechanism.
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