Population
Human embryonic kidney cells expressing L-type Ca2+ channels comprised of either alpha1c subunits alone or…
Comparison
Elevation of intracellular pH from 7.3 to 8.3 by… vs Basal intracellular pH level of 7.3
Design
Preclinical
Authors
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β subunit confers pHi sensitivity to α1c/β2a Ca channels; extends molecular insight but leaves open in vivo cardiac relevance.
The beta subunit of the L-type Ca2+ channel complex is essential for conferring sensitivity to intracellular pH changes.
Schuhmann et al. (1997) studied this question.
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