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May 22, 2001Neurology

Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children

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Key result

Among 31 children with acute disseminated encephalomyelitis, 71% had a prodromal illness, 65% presented with ataxia, and 81% recovered completely.

Why the study?

What are the clinical and neuroradiologic features of acute disseminated encephalomyelitis in children?

Population

31 children who presented to the Royal Children's Hospital in Melbourne with acute disseminated…

Design

Cohort

Authors

JHJenny HynsonMinistry of Public Security of the People's Republic of ChinaAKAndrew J. KornbergRoyal Children's HospitalLCLee ColemanRoyal Children's Hospital

Discussion

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Implication

Common prodromal illness in childhood ADEM warrants vigilance; leaves open vaccine associations for prospective studies.

Study Design

Type

Observational (n=31)

Multicenter

No

Structured PICO

What are the clinical and neuroradiologic features of acute disseminated encephalomyelitis in children?

P
Population
31 children presenting with acute disseminated encephalomyelitis (ADEM) at a single center between 1993 and 1998.
E
Exposure
High-dose IV methylprednisolone
O
Outcome
Clinical and neuroradiologic features

In children with ADEM, a viral prodrome, early-onset ataxia, high MRI lesion load, and deep gray matter involvement help distinguish it from MS, with most patients recovering completely after high-dose IV methylprednisolone.

Limitations

  • Distinction between ADEM and MS cannot be made with certainty at the time of first presentation in the absence of a biological marker.

Cite This Study

Hynson et al. (2001) conducted an observational in Acute disseminated encephalomyelitis (ADEM) (n=31). Acute disseminated encephalomyelitis (ADEM) was evaluated on Clinical and neuroradiologic features. Among 31 children with acute disseminated encephalomyelitis, 71% had a prodromal illness, 65% presented with ataxia, and 81% recovered completely.

synapsesocial.com/papers/6a6ab72e45e10bb5bcf2caeahttps://doi.org/10.1212/wnl.56.10.1308
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