Key result
Corticosteroids are linked to ~100% full recovery in children with acute disseminated encephalomyelitis.
Why the study?
The clinical profile and long-term outcomes of acute disseminated encephalomyelitis in children require detailed characterization.
Design
Observational case series
Follow-up
up to three and a half years
Authors
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Characterizes pediatric ADEM presentation and steroid response; leaves open optimal dosing and long-term outcomes pending larger prospective data.
Observational (n=14)
ADEM in children generally has a good immediate outcome with full recovery following corticosteroid therapy, despite serious neuropsychiatric manifestations.
Jayakrishnan et al. (2010) conducted an observational in Acute disseminated encephalomyelitis (ADEM) (n=14). Intravenous methyl prednisolone followed by oral prednisolone was evaluated on Full recovery. In a cohort of 14 children with acute disseminated encephalomyelitis treated with corticosteroids, 100% recovered fully, with one child developing multiphasic disease on follow-up.
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