Key result
Global heart failure prevalence in young adults increases ~16% from 1990 to 2021.
Why the study?
Heart failure remains a critical global public health priority, but comprehensive epidemiological assessments of the rising number of young heart failure patients are limited.
What is the global burden and etiological profile of heart failure in adolescents and young adults aged 15-44 years?
Observational (n=5,452,015)
What is the global burden and etiological profile of heart failure in adolescents and young adults aged 15-44 years?
Effect estimate: AAPC 0.50% (95% CI 0.49-0.50)
Absolute Event Rate: 156.43% vs 134.51%
p-value: p=<0.001
The global burden of heart failure in individuals aged 15-44 years is substantial and increasing, driven primarily by cardiomyopathy, highlighting the need for early screening and targeted interventions in this demographic.
Alerts clinicians to HF burden in young adults; leaves open targeted prevention research and validation studies.
Introduction: Heart failure (HF) persists as a critical public health priority globally, and comprehensive epidemiological assessments of the rising number of young HF patients remain limited. This study aimed to quantify the global burden of HF among individuals aged 15-44 from 1990 to 2021 and predict until 2050. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, we quantified HF burden among adolescents and young adults (AYA) aged 15-44 years from 1990 to 2021 globally, with stratified by six 5-year age subgroups, sex, sociodemographic index (SDI). Results: In 2021, HF affected 5.45 million cases (age-standardized prevalence rate [ASPR]: 156.43/100,000), with 525,221 YLDs (age-standardized YLD rate [ASYR]: 15.07/100,000) from 1990 to 2021, representing a substantial increase. High SDI regions bore the highest burden. Analyses revealed a consistent male predominance, with the highest burden observed in the 40-44 year age group. Etiologically, cardiomyopathy dominated globally (25.84%). Projections to 2050 forecast continued increase. Conclusion: This study shows HF burden in AYA aged 15-44 years is substantial and continuously growing, characterized by significant gender, age, socio-economic, and geographic differences; cardiomyopathy dominates, highlighting the need for early screening and targeted global health actions.
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Chen et al. (2025) conducted an observational in Heart Failure (n=5,452,015). Time period (2021 vs 1990) vs. 1990 baseline was evaluated on Age-standardized prevalence rate (ASPR) of heart failure per 100,000 persons (AAPC 0.50%, 95% CI 0.49-0.50, p=<0.001). The global age-standardized prevalence rate of heart failure among individuals aged 15-44 years increased significantly from 134.51 per 100,000 in 1990 to 156.43 per 100,000 in 2021.
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