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June 20, 2025European Heart Journal - Quality of Care and Clinical Outcomes

Global burden of heart failure in older adults: trends, socioeconomic inequalities, and future projections from 1990 to 2035

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Key result

Global heart failure cases among older adults increased from 14.1 million in 1990 to 36.2 million in 2021, with the fastest growth in low-to-middle Sociodemographic Index regions.

Why the study?

Despite the growing prevalence of heart failure, comprehensive analyses of HF burden in older adults aged 65 years or older, including trends, causes, and socioeconomic disparities, remain limited.

Population

Older adults aged ≥65 years globally from the Global Burden of Disease Study 2021

Comparison

Burden across Sociodemographic Index quintiles and causes from 1990 to 2021

Design

Cross-sectional temporal trends, decomposition, and Bayesian Age-Period-Cohort modelling study

Authors

JGJianhua GuZZZhaolei ZhengJLJ.S. Li

Discussion

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Member takes

Overview

May warrant prioritized prevention in low-middle SDI older adults; leaves open whether IHD control can flatten the 2035 rise.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

P
Population
Global population of older adults aged ≥65 years analyzed for heart failure burden from 1990 to 2021 using Global Burden of Disease 2021 data.
O
Outcome
Burden of heart failure including prevalence, years lived with disability (YLDs), and underlying causes

The global burden of heart failure in older adults has more than doubled from 1990 to 2021, driven primarily by population growth, with the fastest escalation in low-middle Sociodemographic Index regions.

Cite This Study

Gu et al. (2025) conducted an observational in Heart failure. Time period (1990 to 2021) was evaluated on Heart failure prevalence and years lived with disability (YLDs). Global heart failure cases among older adults increased from 14.1 million in 1990 to 36.2 million in 2021, with the fastest growth in low-to-middle Sociodemographic Index regions.

synapsesocial.com/papers/6a8057205eb4cdfc7531b8fdhttps://doi.org/10.1093/ehjqcco/qcaf047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease Study 20212024 · 36 citations
  2. 2Regional variations in heart failure: a global perspective2023 · 18 citations
  3. 3Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study2019 · 505 citations
  4. 4Sex-specific characteristics and outcomes in hospitalized heart failure with preserved ejection fraction: the China Cardiovascular Association Database-Heart Failure Center Registry2023 · 10 citations
  5. 5Sex-related similarities and differences in responses to heart failure therapies2024 · 32 citations