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This research aims to measure the extracellular space in rabbit heart ventricles using chemical and histological methods.

Chemical and histological space determinations in rabbit heart

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This research aims to measure the extracellular space in rabbit heart ventricles using chemical and histological methods.
Used sucrose and thiocyanate for chemical space estimation.
Applied Chalkley's method post freeze substitution for histological space determination.
Adjusted osmotic activity to induce cell swelling or shrinkage, measuring changes by weighing the heart.
Chemical technique predictions aligned with observed changes in extracellular space in both histological and chemical techniques.
Quantitative agreement with observed values was better in the chemical technique than in the histological method.

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Randomized trial estimates extracellular space changes in rabbit hearts, indicating how osmotic activity impacts cell volume.

Johnson et al. (1962) studied this question.

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