Higher baseline brachial-ankle pulse wave velocity independently predicted new onset of hypertension, with a hazard ratio of 3.49 (95% CI 2.66-4.57) for the highest versus lowest tertile.
Cohort (n=2,496)
No
Does baseline brachial-ankle pulse wave velocity predict new onset of hypertension and longitudinal increases in blood pressure in individuals without hypertension?
Baseline brachial-ankle pulse wave velocity is an independent predictor of longitudinal blood pressure increases and incident hypertension in normotensive individuals.
Hazard Ratio: 3.49 (95% CI 2.66–4.57)
p-value: p=<0.001
BACKGROUND: The present study was designed to test the hypothesis that brachial-ankle pulse wave velocity (baPWV) predicts longitudinal increases in blood pressure (BP) and new onset of hypertension in individuals with normal BP. METHODS: baPWV was measured using a semiautomated device in 2,496 participants (27-84 years) without hypertension who visited our hospital for a yearly health check-up. They were followed up for 4 years with the endpoint being development of hypertension. RESULTS: During the follow-up period (median, 733 days; actual follow-up, 5,215 person-years), hypertension developed in 698 participants (133.8/1,000 person-years). Kaplan-Meier analysis revealed that risk for hypertension was increased across the tertiles of baseline baPWV. The hazard ratio (first tertile as reference) was 2.02 (95% confidence interval (CI) 1.55-2.64) and 3.49 (95% CI 2.66-4.57) in the second and third tertiles, respectively, after adjustment for possible risk factors. Multivariate Cox proportional hazard regression analysis adjusted for known risk factors, where baPWV was used as a continuous variable, also indicated that the baseline value of baPWV independently predicted new onset of hypertension (P < 0.001). Furthermore, baseline baPWV was significantly associated with a longitudinal increase in BP after adjustment for known risk factors in multiple regression analysis (P < 0.001). CONCLUSION: This study provides the first evidence that baPWV is an independent predictor of longitudinal increases in BP as well as of new onset of hypertension.
Takase et al. (Thu,) conducted a cohort in Normal blood pressure (without hypertension) (n=2,496). Brachial-ankle pulse wave velocity (baPWV) vs. First tertile of baseline baPWV was evaluated on Development of hypertension (HR 3.49, 95% CI 2.66-4.57, p=<0.001). Higher baseline brachial-ankle pulse wave velocity independently predicted new onset of hypertension, with a hazard ratio of 3.49 (95% CI 2.66-4.57) for the highest versus lowest tertile.