Key result
Endothelium-dependent vasodilation is exhibited by high-oxidative (SO and FOG type), but not low-oxidative (FG type), rat skeletal muscle, primarily mediated by nitric oxide.
Population
Isolated perfused rat hindlimb preparation
Comparison
Acetylcholine (1-2 x 10 M) and sodium… vs Control (baseline)
Design
Preclinical
Authors
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May support fiber-type differences in endothelium-dependent vasodilation in rat muscle; leaves open translation to human physiology or practice.
p-value: p=<0.05
Endothelium-dependent vasodilation is exhibited by high-oxidative, but not low-oxidative, rat skeletal muscle and appears to be primarily mediated by nitric oxide.
R. M. McAllister (2003) studied this question. Acetylcholine (ACh) and Sodium Nitroprusside (SNP) vs. Control was evaluated on Conductance (p=<0.05). Endothelium-dependent vasodilation is exhibited by high-oxidative (SO and FOG type), but not low-oxidative (FG type), rat skeletal muscle, primarily mediated by nitric oxide.
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