Key result
Cardiovascular autonomic dysfunction (e.g., reduced SDNN) predicted cardiovascular events in CAD patients with T2D in univariate analysis (HR 2.0; 95% CI 1.2-3.1) but not after multivariate adjustment.
Population
1,060 patients with coronary artery disease, mean age 67 ± 8 years, 69% males, 50% with type 2 diabetes.
Design
Cohort
Follow-up
2 years
Authors
Loading...
Autonomic markers should not yet inform T2D prognosis; leaves open hs-CRP as independent predictor.
Cohort (n=1,060)
Hazard Ratio: 2 (95% CI 1.2–3.1)
p-value: p=0.005
Karjalainen et al. (2013) conducted a cohort in Coronary artery disease with and without type 2 diabetes (n=1,060). Cardiovascular autonomic dysfunction (reduced HRR, SDNN, HRT) vs. Normal autonomic function was evaluated on Composite end point of cardiovascular death, acute coronary event, stroke, and hospitalization for heart failure (HR 2.0, 95% CI 1.2-3.1, p=0.005). Cardiovascular autonomic dysfunction (e.g., reduced SDNN) predicted cardiovascular events in CAD patients with T2D in univariate analysis (HR 2.0; 95% CI 1.2-3.1) but not after multivariate adjustment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: