Key result
Urinary levels of sTNF-RI and sTNF-RII correlated significantly with plasma levels (r=0.5 and r=0.4, respectively; p<0.001) and were higher in patients with more severe NYHA class heart failure.
Observational (n=114)
p-value: p=<0.001
Urinary levels of soluble TNF receptors correlate with plasma levels and increase with heart failure severity, suggesting potential diagnostic and prognostic utility.
Urinary cytokine receptor levels may track HF severity; leaves open whether they improve risk stratification or guide therapy.
BACKGROUND: Proinflammatory cytokines are important mediators in heart failure (HF). Recently, urinary levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) have been determined. AIMS: The purpose of this study was to measure the urinary levels of TNF-alpha and IL-6 receptors, sTNF-RI, sTNF-RII, sIL-6R, and the relationship with plasma levels and NYHA classes in HF. METHODS: Plasma and urine were collected from 114 HF patients and sTNF-RI, sTNF-RII and sIL-6R (ng/ml) were analyzed. RESULTS: For the whole population, plasma levels of sTNF-RI were 2.1+/-0.1, of sTNF-RII were 5.0+/-0.3 and of sIL-6R were 49.8+/-2.5. Urinary levels were: sTNF-RI, 2.8+/-0.5, r=0.5, p<0.001; sTNF-RII, 12.6+/-2.1, r=0.4, p<0.001; and sIL-6R, 4.2+/-0.4, NS. In NYHA III subjects, we found sTNF-RI, r=0.6, p<0.01, sTNF-RII, r=0.5, p<0.05, and sILR-6, r=0.5, p<0.05. Both plasma TNF receptors and urinary levels of sTNF-RII were higher in patients in a more severe NYHA class (p<0.05). CONCLUSIONS: Urine is a good environment to study sTNF-RI and sTNF-RII, and this fact has diagnostic and prognostic implications. Plasma and urinary levels of TNF receptors showed a fair correlation, which was increased in higher NYHA classes. Plasma and urinary levels of sIL6R showed a good correlation in NYHA III. The TNF receptor levels in urine increased in patients with more severe HF.
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Rivera et al. (2004) conducted an observational in Heart failure (n=114). Urinary levels of sTNF-RI, sTNF-RII, and sIL-6R was evaluated on Correlation between urinary and plasma levels of sTNF-RI, sTNF-RII, and sIL-6R (p=<0.001). Urinary levels of sTNF-RI and sTNF-RII correlated significantly with plasma levels (r=0.5 and r=0.4, respectively; p<0.001) and were higher in patients with more severe NYHA class heart failure.
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