Key result
Human platelet and cardiac muscle actins are products of different genes, as platelet actin contains threonine and cardiac muscle actin contains valine at position 129.
Population
Human blood platelet actin and human cardiac muscle actin
Design
Preclinical
Authors
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Highlights distinct actin genes in platelets versus heart; leaves open isoform-specific roles in thrombosis or cardiomyopathy.
This basic science study demonstrates that human cytoplasmic (platelet) and myofibrillar (cardiac) actins are products of different genes based on amino acid sequence differences.
Elzinga et al. (1976) studied this question. Human platelet and cardiac muscle actins are products of different genes, as platelet actin contains threonine and cardiac muscle actin contains valine at position 129.
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