Key result
Aging increased forward Na+/Ca2+ exchange-mediated cytosolic Ca2+ clearance (P < 0.05) and prolonged late action potential duration in rat cardiocytes, which were not influenced by run training.
Why the study?
Does treadmill run training influence age-related changes in cardiac Na+/Ca2+ exchange in aged rats?
Population
Male Fischer Brown Norway rats divided into young sedentary, aged sedentary, and aged trained groups
Comparison
8- to 11-wk treadmill run training vs Young sedentary and aged sedentary controls
Design
Preclinical
Follow-up
8 to 11 weeks
Authors
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Aging effects on rat cardiocyte NCX persist despite training; hypothesis-generating for human cardiac aging and exercise.
Does treadmill run training influence age-related changes in cardiac Na+/Ca2+ exchange in aged rats?
p-value: p=<0.05
Aging increases forward Na+/Ca2+ exchange activity in rat cardiocytes, which may explain late action potential prolongation, and this age-related change is not reversed by exercise training.
Mace et al. (2003) studied this question. Treadmill run training vs. Sedentary controls was evaluated on Forward Na+/Ca2+ exchange-mediated [Ca2+]c clearance (p=<0.05). Aging increased forward Na+/Ca2+ exchange-mediated cytosolic Ca2+ clearance (P < 0.05) and prolonged late action potential duration in rat cardiocytes, which were not influenced by run training.
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