Key result
Retigabine (20 µM) delayed the time-to-peak of the compound action potential from 0.27 to 0.34 msec and increased its duration from 3.2 to 4.8 msec in rat sciatic nerves.
Absolute Event Rate: 4.8% vs 3.2%
p-value: p=<0.01
KCNQ2 channels are localized to axon initial segments and nodes of Ranvier, where they regulate axonal excitability, providing a cellular mechanism for neonatal epilepsy and myokymia caused by KCNQ2 mutations.
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Supports KCNQ2 regulation of axonal excitability in rat nerves; leaves open translation to human epilepsy or myokymia.
Devaux et al. (2004) studied this question. Retigabine vs. Baseline was evaluated on Compound action potential (CAP) duration (p=<0.01). Retigabine (20 µM) delayed the time-to-peak of the compound action potential from 0.27 to 0.34 msec and increased its duration from 3.2 to 4.8 msec in rat sciatic nerves.
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