February 1, 2000The Journal of PhysiologyOpen Access

Inhibition of KCNQ1‐4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

View Full Paper

Ask AI

Bookmark

Population

Mammalian Chinese hamster ovary cells stably transfected with M1 muscarinic acetylcholine receptors…

Design

Preclinical

Authors

ASA. A. SelyankoUniversity College London JHJ. K. HadleyUniversity College London IWIan WoodUniversity of Leeds

Discussion

Member takes

Implication

May suppress KCNQ currents via M1 receptors in experimental systems; leaves open physiological relevance in native cardiac tissue.

Structured PICO

Population

Mammalian Chinese hamster ovary (CHO) cells stably transfected with M1 muscarinic acetylcholine receptors expressing KCNQ1-4 potassium channels

Intervention

Stimulation of M1 receptors by 10 microM oxotremorine-M (Oxo-M)

Outcome

Reduction in currents produced by KCNQ1-4 subunitssurrogate

M1 muscarinic receptors couple to all known KCNQ subunits, and their stimulation strongly reduces potassium currents via a diffusible second messenger.

Cite This Study

Selyanko et al. (2000) studied this question.

synapsesocial.com/papers/6a8901033aa2d8278f76034f https://doi.org/10.1111/j.1469-7793.2000.t01-2-00349.x

View Full Paper

Ask AI

Bookmark

Inhibition of KCNQ1‐4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of KCNQ1‐4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider