November 23, 1992Proceedings of the Royal Society B Biological Sciences

Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger

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Population

Dissociated rat superior cervical sympathetic neurons

Comparison

Muscarine applied to the cell membrane outside… vs Muscarine added to the pipette solution

Design

Preclinical

Authors

ASA. A. SelyankoUniversity College London CSCatherine E. StansfeldThe Royal Free Hospital DBDavid A. BrownGalveston College

Discussion

Member takes

Implication

Supports diffusible messenger requirement in M-channel regulation; leaves open translation to human cardiovascular physiology.

Structured PICO

Population

Dissociated rat superior cervical sympathetic neurons

Intervention

Muscarine applied to the cell membrane outside the patch

Comparator

Muscarine added to the pipette solution

Outcome

Single KM(+)-channel current activitysurrogate

Muscarinic acetylcholine-receptor mediated closure of potassium M-channels requires a diffusible intracellular messenger rather than a direct membrane-delimited interaction.

Cite This Study

Selyanko et al. (1992) studied this question.

synapsesocial.com/papers/6a7031818031ec7bb1dc2d59 https://doi.org/10.1098/rspb.1992.0139

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Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider