Muscarinic suppression of the M‐current in the rat sympathetic ganglion is mediated by receptors of the M1‐subtype

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Population

Dissociated adult and foetal rat superior cervical ganglion (s.c.g.) cells and guinea-pig isolated ileum

Design

Preclinical

Authors

Discussion

Supports M1 mediation of muscarinic IM suppression in rat ganglia; leaves open translation to human cardiac autonomic control.

Population

Dissociated adult and foetal rat superior cervical ganglion (s.c.g.) cells and guinea-pig isolated ileum

Intervention

Muscarinic agonists (muscarine, oxotremorine, McN-A-343, methacholine) and antagonists (pirenzepine, AF-DX 116, gallamine, 4-DAMP)

Outcome

Suppression of the M-current (IM) and antagonist affinities (pKB values)surrogate

The suppression of the M-current in rat sympathetic ganglion cells by muscarinic agonists is mediated by M1-subtype receptors.

Marrion et al. (1989) studied this question.

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