June 1, 1989The Journal of PhysiologyOpen Access

On the transduction mechanism for muscarine‐induced inhibition of M‐current in cultured rat sympathetic neurones.

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Population

Dissociated adult or fetal rat superior cervical ganglion cells

Design

Preclinical

Authors

DBDavid A. BrownGalveston College NMNeil V. MarrionElectrophysiology TST.G. SmartUniversity of London

Discussion

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Implication

Elucidates PKC pathway in rat sympathetic M-current inhibition; hypothesis-generating for human autonomic regulation.

Structured PICO

Population

Dissociated adult or fetal rat superior cervical ganglion cells

Intervention

Muscarine (0.4 microM) and various intracellular/extracellular modulators (Gpp(NH)p, GTP-gamma-S, GDP-beta-S, pertussis toxin, cyclic nucleotides, IP3, PDBu)

Outcome

Inhibition of voltage-dependent K+ current, IM (M-current)surrogate

Muscarine inhibits the M-current in rat sympathetic neurons via a pertussis toxin-insensitive GTP-binding protein, potentially involving protein kinase C activation.

Cite This Study

Brown et al. (1989) studied this question.

synapsesocial.com/papers/6a7031c8ce524a4339c3f405 https://doi.org/10.1113/jphysiol.1989.sp017664

View Full Paper

Ask AI

Bookmark

On the transduction mechanism for muscarine‐induced inhibition of M‐current in cultured rat sympathetic neurones.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

On the transduction mechanism for muscarine‐induced inhibition of M‐current in cultured rat sympathetic neurones.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider