February 1, 1991The Journal of PhysiologyOpen Access

Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium.

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Population

Isolated single myocytes from rabbit atrium (211 patches examined)

Design

Preclinical

Authors

MKMuneshige KaibaraNagasaki University TNToshiaki NakajimaElectrophysiology HIHiroshi IrisawaDokkyo Medical University

Discussion

Member takes

Implication

Does not support clinical changes in arrhythmia care; leaves open Mg2+-ATP roles in human atrial K+ channel regulation.

Structured PICO

Population

Isolated single myocytes from rabbit atrium (211 patches examined)

Intervention

Application of ATP, MgCl2, GTP gamma S, pertussis toxin, and AMP-PNP to the internal side of patch membranes

Outcome

Spontaneous opening and activity of muscarinic K+ channelssurrogate

Spontaneous opening of muscarinic K+ channels in rabbit atrial myocytes requires Mg2+ and ATP hydrolysis, independent of muscarinic agonists or pertussis toxin-sensitive G-proteins.

Cite This Study

Kaibara et al. (1991) studied this question.

synapsesocial.com/papers/6a715589f44fa9f079df21dc https://doi.org/10.1113/jphysiol.1991.sp018445

View Full Paper

Ask AI

Bookmark

Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider