Key result
The ACE D, ACTN3 R, and PPARA C gene variants were significantly associated with better performance in strength-related traits, including standing long-jump and handgrip strength, in middle school-age boys.
Why the study?
Are ACE, ACTN3, and PPARA gene variants associated with strength phenotypes in middle school-age children?
Cross-Sectional (n=457)
Single-blind
Yes
Are ACE, ACTN3, and PPARA gene variants associated with strength phenotypes in middle school-age children?
ACE, ACTN3, and PPARA gene variants are associated with strength-related traits in physically active middle school-age boys.
Answers are grounded in this paper and cite their sources.
Should not change youth training or selection practices; leaves open replication to confirm genetic associations with strength.
The aim of the study was to determine the association between ACE I/D, ACTN3 R577X and PPARA intron 7 G/C gene polymorphisms and strength-related traits in 457 middle school-age children (219 boys and 238 girls; aged 11 ± 0.4 years). The assessment of different phenotypes was conducted with a number of performance tests. Gene polymorphisms were determined by PCR. The ACE D allele was associated with high results of standing long-jump test in boys [II 148.3 (16.3) cm, ID 152.6 (19.6) cm, DD 158.2 (19.1) cm; P = 0.037]. The ACTN3 R allele was associated with high results of performance tests in males only in combination with other genes (standing long-jump test: P = 0.021; handgrip strength test: P < 0.0001). Furthermore, the male carriers of the PPARA gene C allele demonstrated the best results of handgrip strength testing than GG homozygotes [GG 14.6 (4.0) kg, GC/CC 15.7 (4.3) kg; P = 0.048]. Thus, the ACE, ACTN3 and PPARA gene variants are associated with strength-related traits in physically active middle school-age boys.
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Ahmetov et al. (2012) conducted a cross-sectional in Healthy physically active children (n=457). ACE, ACTN3, and PPARA gene polymorphisms vs. Alternative genotypes (e.g., II, XX, GG) was evaluated on Standing long-jump test distance (cm) in boys by ACE genotype (p=0.037). The ACE D, ACTN3 R, and PPARA C gene variants were significantly associated with better performance in strength-related traits, including standing long-jump and handgrip strength, in middle school-age boys.
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