Key result
At 6 months of age, functional recovery after ischemia and reperfusion was approximately 60% in Arg389 mice compared to approximately 32% in Gly389 mice.
Population
Transgenic mice with cardiac-specific expression of either human Gly389 or Arg389 beta-AR, and nontransgenic…
Comparison
20 min of ex vivo ischemia and reperfusion (I/R) vs Nontransgenic mice and comparison between Gly389…
Design
Preclinical
Authors
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Arg389 variant linked to better murine recovery; hypothesis-generating for human beta1-adrenergic receptor polymorphisms in ischemia.
Absolute Event Rate: 60% vs 32%
The Arg389 polymorphism of the human beta1-adrenergic receptor appears to confer protection and improved functional recovery after ischemic injury compared to the Gly389 variant through adaptive signaling changes.
Akhter et al. (2006) studied Ischemic injury. Arg389 beta(1)-AR polymorphism vs. Gly389 beta(1)-AR polymorphism was evaluated on Functional recovery after ischemia and reperfusion at 6 months of age. At 6 months of age, functional recovery after ischemia and reperfusion was approximately 60% in Arg389 mice compared to approximately 32% in Gly389 mice.
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