December 25, 2015Current Opinion in Lipidology
Combined hyperlipidemia
Key result
Combined hyperlipidemia is best conceptualized as a multigenic syndrome with a common clinical presentation, modulated by genetic variants and secondary factors like diet and obesity.
Population
Patients with combined hyperlipidemia (CHL)
Design
Review
Authors
Discussion
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Implication
Questions monogenic basis for most CHL; leaves open polygenic modeling of lipid traits and early CVD risk.
Structured PICO
P
Population
Patients with combined hyperlipidemia (CHL)
Combined hyperlipidemia should be viewed as a multigenic syndrome influenced by secondary metabolic factors rather than a single-gene disorder.
Cite This Study
Brahm et al. (2015) conducted a review in Combined hyperlipidemia. Combined hyperlipidemia is best conceptualized as a multigenic syndrome with a common clinical presentation, modulated by genetic variants and secondary factors like diet and obesity.