Key result
This review discusses the interplay between cellular membranes and positive-sense RNA virus replication, focusing on the structural and functional roles of cellular lipids in this process.
This review highlights the structural and functional roles of cellular lipids in the assembly of functional viral RNA replication complexes for positive-sense RNA viruses.
Identifies conserved host membrane remodeling as antiviral target; leaves open mechanistic validation before clinical translation.
Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
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Stapleford et al. (2010) conducted a review in Positive-sense RNA virus infection. Cellular lipids was evaluated. This review discusses the interplay between cellular membranes and positive-sense RNA virus replication, focusing on the structural and functional roles of cellular lipids in this process.
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