Key result
Elevated platelet distribution width (>11.8 fL) in acute coronary syndrome patients was associated with higher GRACE scores (139 vs 126, p=0.025) and reduced TIMI flow grades.
Why the study?
Larger platelet volume is associated with coronary thrombus formation in ACS, prompting evaluation of platelet distribution width levels with clinical severity and extent of CAD.
Is platelet distribution width (PDW) associated with the clinical severity and extent of coronary artery disease in patients with acute coronary syndrome?
Observational (n=1,043)
No
Is platelet distribution width (PDW) associated with the clinical severity and extent of coronary artery disease in patients with acute coronary syndrome?
Absolute Event Rate: 139% vs 126%
p-value: p=0.025
This study investigates whether platelet distribution width can serve as a marker for the severity and extent of coronary artery disease in patients with acute coronary syndrome.
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Polat et al. (2025) conducted an observational in Acute Coronary Syndrome (n=1,043). Platelet distribution width > 11.8 fL vs. Platelet distribution width ≤ 11.8 fL was evaluated on GRACE score (p=0.025). Elevated platelet distribution width (>11.8 fL) in acute coronary syndrome patients was associated with higher GRACE scores (139 vs 126, p=0.025) and reduced TIMI flow grades.
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