Why the study?
Are increased platelet distribution width and mean platelet volume associated with acute STEMI and thrombolysis failure in patients with coronary artery disease?
Are increased platelet distribution width and mean platelet volume associated with acute STEMI and thrombolysis failure in patients with coronary artery disease?
Higher platelet distribution width and mean platelet volume on admission are independent predictors of acute STEMI and thrombolysis failure.
Answers are grounded in this paper and cite their sources.
May identify STEMI patients at higher thrombolysis failure risk; leaves open whether MPV/PDW should guide reperfusion strategy.
We investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both < .001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P = .021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P < .001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI.
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Çetın et al. (2014) studied this question.
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