“Relationship Of Platelet Distribution Width And White Blood Cell Count On Admission With St-Segment Resolution In Patients With St-Elevtion Myocardial Infarction Thrombolysed With Streptokinase”

There is an alarming rise in the incidence and mortality of myocardial infarction. In the context of management of myocardial infarction there are few strategies and indicators to risk stratify patients. Taking the hypothesis that platelets produced during an acute thrombotic event is larger and aggressive we studied the relationship between platelet distribution width (which is a more specific marker of platelet size variation) and the success of thrombolysis in patients with STEMI treated with streptokinase as evidenced by ST segment resolution in ECG after thrombolysis (an ST segment resolution of more than 50% after 60 minutes of thrombolysis is taken as successful thrombolysis). We found that more the Platelet Distribution Width (cut off taken as 12.85) there is more chance of failed thrombolysis. We also studied the relationship between WBC count and ST segment resoulution in the same set of patients and found out that more the WBC count (cut off taken as 12,650 cells per microlitre) at presentation, more is the chance of failure of thrombolysis. Hence these simple markers can be used to prognosticate the treatment and the disease warranting more aggressive and alternative therapies in these set of patients.