March 1, 1983British Journal of Haematology
Arachidonic acid metabolism by platelets of differing size
Key result
The absolute ability of platelets to incorporate arachidonic acid, convert it to active metabolites, and release them is proportional to their mean platelet volume.
Why the study?
Does mean platelet volume affect arachidonic acid metabolism and thromboxane B2 release in human platelets?
Population
Human platelets fractionated into size-dependent subpopulations by counterflow centrifugation
Comparison
Thrombin and collagen stimulation vs Comparison across different mean platelet volumes
Design
Preclinical
Authors
Discussion
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Implication
Platelet reactivity testing should adjust for MPV; leaves open relevance to antiplatelet efficacy in practice.
Structured PICO
Does mean platelet volume affect arachidonic acid metabolism and thromboxane B2 release in human platelets?
P
Population
Human platelets fractionated into size-dependent subpopulations by counterflow centrifugation
E
Exposure
Thrombin and collagen stimulation
C
Comparator
Comparison across different mean platelet volumes (MPV)
O
Outcome
Incorporation and metabolism of tritiated arachidonic acid ([3H]AA) and release of thromboxane B2 (TXB2)surrogate
Larger platelets have a greater absolute capacity to incorporate and metabolize arachidonic acid into active metabolites like thromboxane B2, providing a mechanistic basis for their increased reactivity.
Cite This Study
Jakubowski et al. (1983) studied this question. Mean platelet volume (MPV) vs. Platelets of differing sizes was evaluated on Arachidonic acid incorporation and metabolism. The absolute ability of platelets to incorporate arachidonic acid, convert it to active metabolites, and release them is proportional to their mean platelet volume.