March 1, 1983British Journal of Haematology
Arachidonic acid metabolism by platelets of differing size
Population
Human platelets fractionated into size-dependent subpopulations by counterflow centrifugation
Comparison
Thrombin and collagen stimulation vs Comparison across different mean platelet volumes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for platelet volume modulating reactivity in animals; leaves open human translation and should not change practice.
Structured PICO
P
Population
Human platelets fractionated into size-dependent subpopulations by counterflow centrifugation
I
Intervention
Thrombin and collagen stimulation
C
Comparator
Comparison across different mean platelet volumes (MPV)
O
Outcome
Incorporation and metabolism of tritiated arachidonic acid ([3H]AA) and release of thromboxane B2 (TXB2)surrogate
Larger platelets have a proportionally greater absolute capacity to incorporate and metabolize arachidonic acid into active metabolites, providing a mechanistic basis for their increased reactivity.
Cite This Study
Jakubowski et al. (1983) studied this question.