Why the study?
Does dietary fat composition modify thromboxane A2-induced stimulation of platelets in Wistar rats?
Population
Wistar rats
Comparison
Diets containing high levels of monounsaturated… vs Diet rich in saturated fatty acids
Design
Preclinical
Authors
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Dietary modulation of platelet thromboxane responsiveness in rats does not support clinical recommendations; leaves open human relevance and mechanisms.
Does dietary fat composition modify thromboxane A2-induced stimulation of platelets in Wistar rats?
Dietary fat composition alters platelet signal transduction in response to thromboxane A2, suggesting a compensatory mechanism between thromboxane generation and platelet responsiveness.
Heemskerk et al. (1991) studied this question.
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