Why the study?
Do dietary fats influence ADP-induced platelet thrombosis in rats?
Do dietary fats influence ADP-induced platelet thrombosis in rats?
In a rat model, dietary saturated fats and cholesterol promote ADP-induced platelet thrombosis, whereas unsaturated fats like linseed oil may reduce ADP-induced mortality in females.
Answers are grounded in this paper and cite their sources.
Rat data on dietary fats and ADP thrombosis are hypothesis-generating; clinical relevance in humans remains undetermined.
A thrombotic state, elicited by adenosine diphosphate, was induced in the rat by dietary saturated fats and cholesterol, and was intensified by propylthiouracil. ADP‐induced platelet thrombosis occurred without evidence of prior vascular disease, and the diets alone did not induce thrombosis. Unsaturated fat (linseed oil) in the amounts used, did not significantly affect the incidence of thrombosis. The mortality to ADP was reduced in all female animals supplemented by linseed oil in the diet. The LD50of ADP given intravenously to male rats was found to be 16.6 mg per 100 g body weight.
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Nordøy et al. (1964) studied this question.
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