Key result
In conscious dogs, short-term potentiation of ventilatory output following hypoxic stimulation is masked and expiratory time is prolonged by inhibitory vagal feedback, which is abolished by vagal blockade.
Population
4 conscious recumbent dogs
Comparison
Bilateral cold blockade of the cervical vagus… vs Vagally intact state during the same hypoxic…
Design
Preclinical
Authors
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Vagal masking of hypoxic ventilatory potentiation in dogs leaves open translation to human respiratory control; no clinical implications yet.
Short-term potentiation of ventilatory output following hypoxic stimulation exists in awake dogs, but is masked by an inhibitory vagal feedback memory that prolongs expiratory time.
Xi et al. (1993) studied Conscious dogs (animal model) (n=4). Bilateral cold blockade of the cervical vagus nerves vs. Vagally intact (control) was evaluated on Expiratory time (TE) prolongation following restoration of normoxia. In conscious dogs, short-term potentiation of ventilatory output following hypoxic stimulation is masked and expiratory time is prolonged by inhibitory vagal feedback, which is abolished by vagal blockade.
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