Key result
Dietary sodium depletion increased the renal AT2 receptor signal in mature adult rat kidneys, demonstrating that the receptor is reexpressed in response to sodium depletion after diminishing in adulthood.
The AT2 receptor protein is present in fetal and newborn rat kidneys, decreases in adulthood, but can be upregulated by sodium depletion.
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AT2 receptor protein is expressed in fetal/newborn but not adult rat kidney; leaves open its role in human renal development.
Ozono et al. (1997) studied this question. Dietary sodium depletion vs. Normal sodium intake was evaluated on AT2 receptor protein expression. Dietary sodium depletion increased the renal AT2 receptor signal in mature adult rat kidneys, demonstrating that the receptor is reexpressed in response to sodium depletion after diminishing in adulthood.
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