Population
Rat fetal tissues from day 11 to 19 of gestation and young rats from day 0 to 10 postpartum
Design
Preclinical
Authors
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AT1A exclusivity in fetal tissues suggests developmental roles for angiotensin II; hypothesis-generating and requires human validation before any clinical consideration.
The differential spatiotemporal expression of AT1 receptor subtypes suggests angiotensin II may play a role as a differentiation factor during organogenesis.
Shanmugam et al. (1994) studied this question.
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