Differential localization of angiotensin II receptor subtypes in the rat brain suggests AT1A mediates known central functions of angiotensin II, while AT2 may be involved in sensory and motor functions.
Answers are grounded in this paper and cite their sources.
Differential AT1/AT2 mapping in rat brain; leaves open subtype-specific roles in human central cardiovascular regulation.
We localized the gene expression of angiotensin II receptor subtypes (AT1A, AT1B, and AT2) in 2-week-old rat brain by in situ hybridization using subtype specific riboprobes. AT1A receptor mRNA but not AT1B or AT2 receptor mRNA was expressed in the subfornical organ and paraventricular nucleus of the hypothalamus. AT1B as well as AT1A receptor mRNA were found in the cerebral cortex and hippocampus. Conversely, AT2 receptor mRNA, but not AT1A or AT1B, was expressed in the medial geniculate nucleus and inferior olive. Our results indicate that AT1A receptors are involved in the well known central functions of angiotensin II. These results also support the hypothesis of the involvement of AT2 receptors in sensory and motor function.
No takes yet. Share an insight, caveat, or question.
Jöhren et al. (1995) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: